Symptoms and treatment of leukemia

summary

Some chemicals can cause leukemia. The incidence of leukemia in the population exposed to benzene and its derivatives was higher than that in the general population. There are also reports of leukemia induced by nitrosamines, bentazone and its derivatives, chloramphenicol, etc. Some anti-tumor cytotoxic drugs, such as nitrogen mustard, cyclophosphamide, methylbenzylhydrazine, VP16, VM26 and so on, can induce leukemia. The symptom of leukaemia and treatment? Let's talk about it

Symptoms and treatment of leukemia

The symptoms were fever and heat type. The main cause of fever is infection, in which angina, stomatitis, perianal infection are the most common, pneumonia, tonsillitis, gingivitis, perianal abscess are also more common. Ear inflammation, enteritis, carbuncle, pyelonephritis can also be seen, severe sepsis, sepsis, etc. Fever can also be a symptom of acute leukemia itself without any signs of infection.

The bleeding site can be all over the body, with skin, gum, nasal bleeding the most common, also can have retinal, ear bleeding and intracranial, digestive tract, respiratory tract and other visceral bleeding. Female menorrhagia is also more common, can be the first symptom.

Leukemic infiltration of bone and periosteum causes bone pain, which can be diffuse pain in limbs or back, or limited to joint pain, often leading to difficulty in movement. More than one third of the patients had tenderness of the sternum, which is helpful for the diagnosis of the disease. Bacteria are the most common pathogens. In the late stage of the disease, the possibility of fungal infection gradually increases due to the long-term use of granulocytes lower than normal and broad-spectrum antibiotics. Although virus infection is rare, it is dangerous and should be paid attention to.

matters needing attention

Due to the success of targeted therapy and apoptosis inducing therapy, PML-RAR has been widely used α Positive acute promyelocytic leukemia (M3) is the best type of prognosis in AML. More and more studies show that all trans retinoic acid combined with arsenic can cure the vast majority of M3 patients. The treatment should be carried out strictly according to the course of treatment, and the length of maintenance treatment in the later stage is mainly determined by the residue of fusion gene.