How to diagnose and differentiate light chain disease and light chain deposition disease?

summary

Light chain disease and light chain deposition disease are plasma cell dysplasia. The reason is that the abnormal plasma cells produce too many light chains, while the synthesis of heavy chains decreases correspondingly. Light chain disease (LCD) is caused by excessive free light chain fragments in serum or urine; Once the immunoglobulin light chain is deposited in the whole body, the corresponding clinical manifestation is called light chain deposition disease. How to diagnose and differentiate light chain disease and light chain deposition disease? Now let me tell you something.

How to diagnose and differentiate light chain disease and light chain deposition disease?

Moreover, the type of light chain deposited in tissue is consistent with the production of abnormal plasma cells in bone marrow. Kidney damage complications mainly include nephrotic syndrome, chronic interstitial nephritis, acute and chronic renal insufficiency, etc. Therefore, we need to pay attention to and protect carefully, otherwise the consequences are very serious.

Just like primary amyloidosis, the clinical manifestations vary with the location and degree of deposition of monoclonal protein in organs. In most typical cases, heart, nerve, liver and kidney are involved, as well as skin, spleen, thyroid, suprarenal gland and gastrointestinal tract.

The manifestations of the disease are anemia, fever, weakness, bleeding tendency, superficial lymph nodes, liver and spleen enlargement, and then localized or multiple bone pain, pathological fracture or local tumor. Limited bone destruction or defect. It is easy to be complicated with repeated respiratory and digestive system infections.

matters needing attention

Try to eat less animal viscera, fish, shrimp, crab, hot pot soup, thick fish soup, chicken soup and so on, sugar, honey and so on are not suitable for eating. Beans in vegetables, such as lentils and broad beans, should be eaten less. But yogurt is not suitable for drinking. Pepper, pepper, curry, pepper, espresso and other stimulating diet should be as little as possible to eat.