Causes of proteinuria

summary

Abdominal distension, crus is swollen, sleep is not good, the eye is dry, albuminuria 2 plus sign, after treatment already improved, so albuminuria reason? Now let's take a look at it!

Causes of proteinuria

Reason 1: mesangial toxicity of proteinuria: in the model of renal failure, the accumulation of serum protein in glomerular mesangium can be observed. The accumulation of these macromolecular substances in mesangial area can cause mesangial cell damage and proliferation, and increase the synthesis of mesangial matrix, resulting in glomerulosclerosis.

Reason 2: the toxic effect of proteinuria on proximal convoluted tubular cells: when proteinuria occurs, the amount of protein entering the epithelial cells of renal tubules increases, which increases the activity of lysosomes, suggesting that protein causes lysosomes to overflow into the cytoplasm of tubular cells, and subsequent cell damage can stimulate inflammation and scar formation.

The third reason: the biological changes of tubular cells caused by proteinuria: many kidney diseases with proteinuria have excessive cell proliferation, which represents a non adaptive response and leads to renal failure. More and more evidences show that proteins can directly regulate the function of tubular cells, change their growth characteristics and the phenotypic expression of cytokines and matrix proteins, which can lead to the release of PDGF, FN and MCP-1 from the basal side of tubular cells and induce fibrosis.

matters needing attention

Warm reminder: Patients with urinary protein plus sign must pay great attention to it. They should go to the hospital for detailed examination and comprehensive treatment. At the same time, they should pay attention to their diet. They should eat heat clearing and diuretic food with low sugar content. They should not eat hair food, too much salt and too dry food.